The effect of sublingual nifedipine on uteroplacental blood flow in hypertensive pregnancy.
Identifieur interne : 005B69 ( Main/Exploration ); précédent : 005B68; suivant : 005B70The effect of sublingual nifedipine on uteroplacental blood flow in hypertensive pregnancy.
Auteurs : RBID : pubmed:3224091English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Nifedipine.
- blood supply : Placenta, Uterus.
- drug effects : Blood Flow Velocity, Blood Pressure, Pulse.
- drug therapy : Hypertension, Pregnancy Complications, Cardiovascular.
- Adult, Female, Humans, Pregnancy.
Abstract
The effect of nifedipine on uteroplacental blood flow was investigated in nine hypertensive women in the trimester of pregnancy and compared with the effects of a placebo in nine similar hypertensive women. An index of uteroplacental blood flow was obtained, twice before treatment and once after treatment, by measuring the increase in radioactivity in the region of the placenta with a gamma camera following an intravenous injection of indium-113m. There was no significant change in the blood flow index in either the nifedipine- or the placebo-treated groups despite a significant fall in blood pressure with nifedipine. Nifedipine lowers the blood pressure without any apparent reduction in uteroplacental blood flow.
PubMed: 3224091
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The effect of sublingual nifedipine on uteroplacental blood flow in hypertensive pregnancy.</title><author><name sortKey="Lindow, S W" uniqKey="Lindow S">S W Lindow</name><affiliation wicri:level="1"><nlm:affiliation>Department of Obstetrics and Gynaecology, University of Cape Town Medical School, Observatory, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Department of Obstetrics and Gynaecology, University of Cape Town Medical School, Observatory</wicri:regionArea></affiliation></author><author><name sortKey="Davies, N" uniqKey="Davies N">N Davies</name></author><author><name sortKey="Davey, D A" uniqKey="Davey D">D A Davey</name></author><author><name sortKey="Smith, J A" uniqKey="Smith J">J A Smith</name></author></titleStmt><publicationStmt><date when="1988">1988</date><idno type="RBID">pubmed:3224091</idno><idno type="pmid">3224091</idno><idno type="wicri:Area/Main/Corpus">005F18</idno><idno type="wicri:Area/Main/Curation">005F18</idno><idno type="wicri:Area/Main/Exploration">005B69</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Blood Flow Velocity (drug effects)</term><term>Blood Pressure (drug effects)</term><term>Female</term><term>Humans</term><term>Hypertension (drug therapy)</term><term>Nifedipine (therapeutic use)</term><term>Placenta (blood supply)</term><term>Pregnancy</term><term>Pregnancy Complications, Cardiovascular (drug therapy)</term><term>Pulse (drug effects)</term><term>Uterus (blood supply)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Nifedipine</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Placenta</term><term>Uterus</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blood Flow Velocity</term><term>Blood Pressure</term><term>Pulse</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hypertension</term><term>Pregnancy Complications, Cardiovascular</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Pregnancy</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effect of nifedipine on uteroplacental blood flow was investigated in nine hypertensive women in the trimester of pregnancy and compared with the effects of a placebo in nine similar hypertensive women. An index of uteroplacental blood flow was obtained, twice before treatment and once after treatment, by measuring the increase in radioactivity in the region of the placenta with a gamma camera following an intravenous injection of indium-113m. There was no significant change in the blood flow index in either the nifedipine- or the placebo-treated groups despite a significant fall in blood pressure with nifedipine. Nifedipine lowers the blood pressure without any apparent reduction in uteroplacental blood flow.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">3224091</PMID><DateCreated><Year>1989</Year><Month>04</Month><Day>04</Day></DateCreated><DateCompleted><Year>1989</Year><Month>04</Month><Day>04</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0306-5456</ISSN><JournalIssue CitedMedium="Print"><Volume>95</Volume><Issue>12</Issue><PubDate><Year>1988</Year><Month>Dec</Month></PubDate></JournalIssue><Title>British journal of obstetrics and gynaecology</Title><ISOAbbreviation>Br J Obstet Gynaecol</ISOAbbreviation></Journal><ArticleTitle>The effect of sublingual nifedipine on uteroplacental blood flow in hypertensive pregnancy.</ArticleTitle><Pagination><MedlinePgn>1276-81</MedlinePgn></Pagination><Abstract><AbstractText>The effect of nifedipine on uteroplacental blood flow was investigated in nine hypertensive women in the trimester of pregnancy and compared with the effects of a placebo in nine similar hypertensive women. An index of uteroplacental blood flow was obtained, twice before treatment and once after treatment, by measuring the increase in radioactivity in the region of the placenta with a gamma camera following an intravenous injection of indium-113m. There was no significant change in the blood flow index in either the nifedipine- or the placebo-treated groups despite a significant fall in blood pressure with nifedipine. Nifedipine lowers the blood pressure without any apparent reduction in uteroplacental blood flow.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lindow</LastName><ForeName>S W</ForeName><Initials>SW</Initials><Affiliation>Department of Obstetrics and Gynaecology, University of Cape Town Medical School, Observatory, South Africa.</Affiliation></Author><Author ValidYN="Y"><LastName>Davies</LastName><ForeName>N</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Davey</LastName><ForeName>D A</ForeName><Initials>DA</Initials></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>J A</ForeName><Initials>JA</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Clinical Trial</PublicationType><PublicationType>Controlled Clinical Trial</PublicationType><PublicationType>Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>ENGLAND</Country><MedlineTA>Br J Obstet Gynaecol</MedlineTA><NlmUniqueID>7503752</NlmUniqueID><ISSNLinking>0306-5456</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>I9ZF7L6G2L</RegistryNumber><NameOfSubstance>Nifedipine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Blood Flow Velocity</DescriptorName><QualifierName MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Blood Pressure</DescriptorName><QualifierName MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Hypertension</DescriptorName><QualifierName MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Nifedipine</DescriptorName><QualifierName MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Placenta</DescriptorName><QualifierName MajorTopicYN="Y">blood supply</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Pregnancy Complications, Cardiovascular</DescriptorName><QualifierName MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Pulse</DescriptorName><QualifierName MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Uterus</DescriptorName><QualifierName MajorTopicYN="Y">blood supply</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1988</Year><Month>12</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1988</Year><Month>12</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1988</Year><Month>12</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">3224091</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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